Isabel Sanford (born Eloise Gwendolyn Sanford; August 29, 1917 – July 9, 2004) was an American stage, film and television actress best known for her role as Louise "Weezy" Mills-Jefferson on the CBS sitcoms All in the Family (1971–1975) and The Jeffersons (1975–1985). In 1981, she became the first black American actress to win a Primetime Emmy Award for Outstanding Lead Actress in a Comedy Series.
Sanford was married to house painter William Edward "Sonny" Richmond. The couple had three children, two sons and a daughter, before separating. After their separation, Sanford and the children moved to California in 1960 while Richmond remained in New York. Shortly after their arrival, Richmond died after being involved in an altercation.
In September 2003, Sanford underwent preventive surgery on her carotid artery. In the ensuing months, her health steadily declined. She was hospitalized at Cedars-Sinai Medical Center on July 4, 2004 where she died five days later. Her publicist did not announce a cause of death, instead attributing it to unspecified "natural causes." She was interred at Forest Lawn Memorial Park, Hollywood Hills in Los Angeles.
For her contribution to the television industry, Isabel Sanford has a star on the Hollywood Walk of Fame located at 7080 Hollywood Boulevard.